Microwave-assisted solid-phase synthesis of peptoids.
نویسندگان
چکیده
Microwave irradiation reduces the reaction time for the solid-phase synthesis of peptoids. Under these conditions, coupling of each residue requires only 1 min. The purity and yields of peptoids synthesized in this way are as good as or better than those achieved using standard methods. [reaction: see text]
منابع مشابه
Microwave-assisted Solid-phase(SPPS) and Solution-phase (SPS) Synthesis of Biological Dipeptide ((β-alanine-L histidine)
Peptides have shown Promising effect as pharmaceutics with the potential to treat a widevariety of diseases. Peptides are mostly synthesized by biological technology or chemicalmethods. Solution phasepeptide synthesis (SPS) and solid phase peptide synthesis (SPPS) aretwo major chemical techniques for peptidesproduction.In this research, the synthesis ofdipeptde(β-alanine-L-histidine)wasexamined...
متن کاملCross metathesis assisted solid-phase synthesis of glycopeptoids.
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modificati...
متن کاملFast and efficient microwave-assisted synthesis of functionalized peptoids via Ugi reactions.
A wide range of N-alkylglycines (peptoids) can be efficiently prepared via Ugi reactions using microwave irradiations. The results confirm the versatility and efficiency of the methodology for the preparation of functionalized peptoids. The products can be used in consecutive Ugi reactions to yield cyclic peptoids of potential biological interest.
متن کاملMicrowave-assisted one-pot synthesis of 1-amidoalkyl 2-naphthols and dibenzo [a,j] xanthenes using phosphorus pentoxide on solid supports
A convenient, efficient and practical procedure for the synthesis of 1-amidoalkyl 2-naphthols is described by condensation of aromatic aldehydes with amides and 2-naphthol in the presence of P2O5/SiO2 as an efficient catalyst. Moreover, in the present of this catalyst, the synthesis of 14-aryl or alkyl-14H-dibenzo[a,j]xanthenes is studied by co...
متن کاملMicrowave-assisted one-pot synthesis of 1-amidoalkyl 2-naphthols and dibenzo [a,j] xanthenes using phosphorus pentoxide on solid supports
A convenient, efficient and practical procedure for the synthesis of 1-amidoalkyl 2-naphthols is described by condensation of aromatic aldehydes with amides and 2-naphthol in the presence of P2O5/SiO2 as an efficient catalyst. Moreover, in the present of this catalyst, the synthesis of 14-aryl or alkyl-14H-dibenzo[a,j]xanthenes is studied by co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic letters
دوره 4 23 شماره
صفحات -
تاریخ انتشار 2002